| Date | Location | Result | |
| Nov 13, 2021 | Alva, Oklahoma | Northwestern Okla. 31, Southwestern Okla. 28 | Box score |
| Nov 06, 2021 | Searcy, Arkansas | Harding 55, Southwestern Okla. 7 | Box score |
| Oct 30, 2021 | Weatherford, | Arkansas Tech 15, Southwestern Okla. 14 | Box score |
| Oct 23, 2021 | Weatherford, Oklahom | Ouachita Baptist 44, Southwestern Okla. 34 | Box score |
| Oct 14, 2021 | Bethany, | Southern Nazarene 30, Southwestern Okla. 22 | Box score |
| Oct 09, 2021 | Weatherford, | Ouachita Baptist 30, Southwestern Okla. 10 | Box score |
| Oct 02, 2021 | Monticello, Arkansas | Ark.-Monticello 18, Southwestern Okla. 16 | Box score |
| Sep 25, 2021 | Weatherford, | Okla. Baptist 31, Southwestern Okla. 27 | Box score |
| Sep 18, 2021 | Durant, Oklahoma | Southeastern Okla. 37, Southwestern Okla. 28 | Box score |
| Sep 11, 2021 | Magnolia, Arkansas | Southern Arkansas Un 42, Southwestern Okla. 27 | Box score |
| Sep 02, 2021 | Weatherford, Oklahom | Henderson St. 31, Southwestern Okla. 13 | Box score |