| Date | Location | Result | |
| 11/19/21 | Hot Springs, AR | Arkansas Tech 3, Southwestern Okla 1 (25-19,25-22,20-25,25-14) | Box score |
| 11/18/21 | Hot Springs, AR | Southwestern Okla 3, Southeastern Okla. 0 (24-17,25-16,25-10) | Box score |
| 11/12/21 | Alva, OK | Southwestern Okla 3, Northwestern Okla. 2 (26-28,25-17,28-26,20-25,15-12) | Box score |
| 11/09/21 | Shawnee, OK | Okla. Baptist 3, Southwestern Okla 1 (25-12,20-25,25-14,25-22) | Box score |
| 11/04/21 | Bethany, OK | Southwestern Okla 3, Southern Nazarene 1 (26-28,25-19,25-22,25-11) | Box score |
| 11/02/21 | Durant, OK | Southwestern Okla 3, St. Edward's 1 (25-21,23-25,25-22,25-18) | Box score |
| 10/28/21 | Weatherford, OK | Southwestern Okla 3, East Central 2 (20-25,20-25,25-16,25-23,15-11) | Box score |
| 10/23/21 | Monticello, AR | Southwestern Okla 3, Ark.-Monticello 2 (21-25,26-24,23-25,25-22,15-9) | Box score |
| 10/22/21 | Magnolia, AR | Southwestern Okla 3, Southern Ark. 1 (22-25,25-20,27-25,25-21) | Box score |
| 10/19/21 | Weatherford, OK | Southwestern Okla 3, Okla. Christian 0 (25-10,25-16,25-16) | Box score |
| 10/16/21 | Weatherford, OK | Southwestern Okla 3, Arkansas Tech 0 (25-22,25-19,25-17) | Box score |
| 10/15/21 | Weatherford, OK | Southwestern Okla 3, Harding 0 (25-23,25-19,25-16) | Box score |
| 10/08/21 | Arkadelphia, AR | Southwestern Okla 3, Ouachita Baptist 0 (25-21,25-14,25-11) | Box score |
| 10/07/21 | Arkadelphia, AR | Henderson St. 3, Southwestern Okla 1 (25-23,26-24,22-25,25-20) | Box score |
| 10/02/21 | Weatherford, OK | Southwestern Okla 3, Randall 0 (25-7,25-18,25-14) | Box score |
| 09/30/21 | Weatherford, OK | Southwestern Okla 3, Southern Nazarene 1 (25-19,21-25,25-18,25-11) | Box score |
| 09/28/21 | Weatherford, OK | Southwestern Okla 3, Northwestern Okla. 2 (18-25,19-25,25-19,25-20,15-10) | Box score |
| 09/24/21 | Ada, OK | East Central 3, Southwestern Okla 2 (25-18,17-25,17-25,25-18,15-7) | Box score |
| 09/21/21 | Weatherford, OK | Southwestern Okla 3, Southeastern Okla. 0 (25-13,25-20,25-21) | Box score |
| 09/16/21 | Weatherford, OK | Southwestern Okla 3, Okla. Baptist 2 (22-25,25-19,25-16,20-25,16-14) | Box score |
| 09/11/21 | Denton, TX | Southwestern Okla 3, Texas Woman's 1 (15-25,25-18,25-19,25-13) | Box score |
| 09/11/21 | Denton, TX | Southwestern Okla 3, Tex. Permian Basin 0 (25-21,25-14,25-13) | Box score |
| 09/10/21 | Denton, TX | Southwestern Okla 3, Southwest Baptist 1 (25-17,18-25,25-23,25-23) | Box score |
| 09/09/21 | Denton, TX | Southwestern Okla 3, Florida Tech 1 (25-11,18-25,25-16,25-11) | Box score |
| 09/04/21 | Canyon, TX | St. Edward's 3, Southwestern Okla 0 (29-27,25-18,25-13) | Box score |
| 09/04/21 | Canyon, TX | West Tex. A&M 3, Southwestern Okla 1 (23-25,25-22,25-18,25-22) | Box score |
| 09/03/21 | Canyon, TX | Ark.-Fort Smith 3, Southwestern Okla 1 (25-20,24-26,26-24,25-15) | Box score |
| 09/03/21 | Canyon, TX | Tex. Permian Basin 3, Southwestern Okla 1 (21-25,25-21,25-19,25-11) | Box score |